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Can You Take Phentermine With Metformin?

In this article, we will take a close look at Phentermine, a sympathomimetic amine used for short-term weight loss, and Metformin, a medication used to treat type 2 diabetes and prediabetes. We will explore whether these two medications can be taken together and discuss their potential side effects.

Nithishwer Mouroug Anand

Author - Nithishwer Mouroug Anand

Nithish is a computational biochemist at the University of Oxford working on alchemical methods for protein-drug interactions.

Nithishwer used MediSearch to find sources for this blog.
MediSearch gives instant answers to medical questions based on 30 million scientific articles.

What is Phentermine?

Phentermine is a sympathomimetic amine often used for short-term weight loss. It is an appetite suppressant designed to combat obesity by decreasing appetite and increasing satiety.[1].

Phentermine is approved for "short-term" treatment of patients with obesity [2]. It is effective in promoting weight loss when combined with other drugs, such as topiramate [3, 4, 5]. However, it's important to note that Phentermine should not be used with certain other medications due to the risk of severe side effects [3].

What is Metformin?

Metformin is a medication used to treat type 2 diabetes and prediabetes. It works by decreasing the amount of glucose your liver releases and increasing your body's response to insulin. Metformin is also used in combination with other medications to treat polycystic ovary syndrome (PCOS) [4].

Metformin is commonly prescribed to manage type 2 diabetes. Metformin is used daily by 150 million people worldwide [5]. Recent studies have also suggested that metformin may have additional medical benefits beyond treating diabetes, revealing its potential therapeutic uses [6].

Can Phentermine and Metformin be taken together?

The question of whether Phentermine and metformin can be taken together is a valid one, especially for patients who are dealing with both obesity and diabetes.

Taking Phentermine and Metformin together may cause a significant drop in your blood sugar levels [7]. This could lead to hypoglycemia, a condition characterised by abnormally low blood sugar levels, which can cause symptoms such as dizziness, confusion, and, in severe cases, loss of consciousness.

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