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Dihexa Peptide: Benefits and Side Effects

In this article, we will take a close look at Dihexa peptide, a derivative of angiotensin IV-related molecules known for their cognitive-enhancing and anti-dementia effects. We will discuss its mechanism of action, its potential benefits, particularly in the context of Alzheimer's disease, and its possible side effects.

Nithishwer Mouroug Anand

Author - Nithishwer Mouroug Anand

Nithish is a computational biochemist at the University of Oxford working on alchemical methods for protein-drug interactions.

Nithishwer used MediSearch to find sources for this blog.
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What is the Dihexa peptide?

Dihexa peptide, also called N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is a derivative of angiotensin IV-related molecules that can cross the blood-brain barrier. These molecules are recognized for their cognitive-enhancing and anti-dementia effects, positioning them as promising candidates for therapeutic drug development [1].

How does dihexa peptide work?

Dihexa peptide attaches with high affinity to hepatocyte growth factor (HGF), a protein involved in cell growth and movement. This binding activates c-Met phosphorylation, which turns on the HGF receptor and triggers a series of signalling events. This process stimulates the formation of new synapses and spines in the hippocampus, much like HGF. These actions contribute to the cognitive-enhancing effects of Dihexa [2].

Uses and benefits of dihexa peptides

Dihexa has shown promising benefits in various studies, particularly in the context of cognitive enhancement and neuroprotection. One of the key benefits of Dihexa is its potential as an antidementia therapeutic. It has been recognized as a procognitive agent with the ability to reverse scopolamine-induced deficits in Morris water maze performance and augment hippocampal synaptogenesis, suggesting its potential in treating disorders like Alzheimer's disease [1].

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In Alzheimer's disease models, Dihexa has been found to restore spatial learning and cognitive functions, decrease the activation of astrocytes and microglia, reduce levels of pro-inflammatory cytokines, and increase levels of anti-inflammatory cytokines. These findings suggest that Dihexa could be a potential treatment for Alzheimer's disease [3].

Side effects of dihexa peptide

Some potential side effects of Dihexa peptide may include:

  • Bleeding problems - Symptoms can include red or purple spots on the skin, bruising more easily than normal, and bleeding from the mouth or nose [4]
  • Allergic reactions - Fever, skin rash, hives, sores in the mouth, blistering and peeling of the skin, swelling of lymph nodes, face, eyes, lips, tongue or throat, and trouble swallowing [5]

However, we have to keep in mind that there isn't enough data on the side effects of Dihexa.

More research would be needed to fully characterise the side effects and safety of Dihexa peptide. Therefore it is crucial to refer to a doctor before starting a new regiment.

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