Hexarelin vs Ipamorelin: Differences and Similarities

In this article, we will take a close look at Hexarelin and Ipamorelin, two synthetic peptides that stimulate the release of growth hormone. We will analyze their cardioprotective and neuroprotective functions, their role in growth stimulation, and their differences in terms of potency and selectivity.
Frederika Malichová

Frederika Malichová

Neuroscientist at the University Of Cambridge.

A blue image with text saying "Understanding Hexarelin and Ipamorelin: A Comparative Study"

What is Hexarelin?

Hexarelin is a synthetic growth hormone-releasing peptide with protective effects in the cardiovascular system and nervous system and stimulating effects on growth [1, 2].

In terms of its cardioprotective functions, it has been found to show protection in diseases like myocardial infarction and atherosclerosis [2]. Further, it showed cardioprotective actions in ischemia and reperfusion injury [3].

Hexarelin is also involved in the protection of the nervous system. In particular, studies showed that hexarelin treatment in animal murine models reduced brain damage by 39%. [4]

Further, hexarelin has been shown to stimulate growth in short children by increasing insulin-like growth factor (IGF-I) secretion and velocity [4].

Hexarelin is a synthetic peptide and its natural analog is called ghrelin. Ghrelin binds to and activates the growth hormone secretagogue receptor in the brain. Hexarelin simulates its effect, but it is chemically more stable and functionally more potent than ghrelin [1].

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There is evidence to suggest that Ipamorelin, a growth hormone secretagogue and agonist of the ghrelin receptor, may have potential benefits for digestive health recovery. Studies have shown that Ipamorelin can accelerate gastric emptying, enhance gastric motility, and improve symptoms in conditions like postoperative ileus. It has also been found to stimulate appetite and increase fecal pellet output. However, more research is needed to fully understand its effects and determine its efficacy in promoting digestive health recovery. [1] [2] [3]

Ipamorelin is a potent growth hormone (GH)-releasing peptide that has been compared to other GH-releasing peptides in various studies. In terms of GH release potency and efficacy, Ipamorelin has been found to be similar to GHRP-6 and GHRP-2 [1]. It stimulates GH release via a GHRP-like receptor [1]. In terms of in vivo potency, Ipamorelin has been shown to have comparable effects to GHRP-6 in rats and conscious swine [1]. However, GHRP-2 displayed higher potency but lower efficacy compared to Ipamorelin and GHRP-6 [1]. Ipamorelin is the first GHRP-receptor agonist with a selectivity for GH release similar to that displayed by GHRH [1]. Overall, Ipamorelin shows promising similarities to other GH-releasing peptides in terms of GH release and potency.

What is Ipamorelin?

Ipamorelin is a synthetic peptide, which consists of five amino acids. It is a patent and specific peptide promoting the release of growth hormone (GH) in the body [5].

Interestingly, it is a selective stimulator of the growth hormone, which means that it does not affect other hormonal levels. Typically, when dealing with other growth hormone-releasing peptides, they affect the levels of cortisol or prolactin. Because of this specific selective function, ipamorelin is an interesting candidate for future clinical studies [6].

Ipamorelin can affect various aspects of health such as bone growth, body weight and gastric motility. According to research, it can increase longitudinal (long-term) bone growth rate and body weight in rats [5]. Staying with rats, it also seems to accelerate gastric emptying of postoperative ileus [7]. In GH-deficient mice, Ipamorelin was found to increase body fat of these. These findings suggest that indeed Ipamorelin can be found to work in bone development and growth, gastrointestinal tract and also might have a GH-independent mechanism of action.

What are the differences between Hexarelin and Ipamorelin?

Both Hexarelin and Ipamorelin are synthetic peptides simulating the release of GH. Although they simulate the same hormone, they have different properties and effects.

While both of these molecules are potent and their GH-releasing activity is dose-dependent, Hexarelin has been found to influence the levels of prolactin-releasing activity, and Ipamorelin has not been to [5, 6, 8, 9].

In conclusion, while both Hexarelin and Ipamorelin stimulate the release of GH, they differ in their potency, selectivity, and the other hormones they affect. Hexarelin has a broader hormone-releasing activity, while Ipamorelin is more selective for GH release. Importantly both of these peptides have a wide range of potential therapeutic applications in the area of growth!

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Frederika Malichová

Frederika Malichová

Frederika is a postgraduate researcher at the University of Cambridge, where she investigates new biomarkers for Frontotemporal Dementia and other tauopathies. Her research has been published at prestigious conferences such as the Alzheimer’s Association International Conference 2023. She obtained her BSc in Biomedical Sciences from UCL, where she worked closely with the UK Dementia Research Institute.