The M367 Pill: A Combination of Hydrocodone and Acetaminophen

The M367 White Oval Pill is prescription medication used primarily for pain relief. It is a combination of hydrocodone bitartrate, a potent opioid, and acetaminophen. In this article, we will understand what M367 is, its side effects, risks of abuse and addiction, and the risks and dangers of mixing M367 with other substances.
Nithishwer Mouroug Anand

Nithishwer Mouroug Anand

Nithish is a computational biochemist at the University of Oxford working on alchemical methods for protein-drug interactions.

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What is the M367 White Oval Pill?

The M367 White Pill is a prescription painkiller. It is used for managing both chronic and acute pain. It is used to treat postoperative pain (pain which occurs after surgery), pain coming from musculoskeletal injury (a broken limb) or chronic pain that is a result of a serious condition, like cancer.

From a chemical perspective, the active ingredients in M367 are a combination of hydrocodone bitartrate (10mg), a semi-synthetic opioid analgesic, and acetaminophen (325mg). Acetaminophen, also known as paracetamol, is a non-opioid analgesic and antipyretic agent used to treat less severe pain. It can be found in many over-the-counter drugs, such as Tylenol or Panadol. [1]

Even though Hydrocodone bitartrate is a more potent pain reliever than Acetaminophen, Acetaminophen can increase the effects of hydrocodone [2].

Hydrocodone bitartrate works by binding to opioid receptors in the brain, called the mu-opioid receptors. After hydrocodone binds to the receptors, it blocks the transmission of pain signals. This reduces the pain that we feel.

Interestingly, the exact mechanism of action of Acetaminophen is not fully understood. It's believed to inhibit cyclooxygenase enzymes, particularly in the central nervous system, reducing the production of prostaglandins which signal pain and fever [3]. It may also affect the endocannabinoid and serotonergic systems, and interact with transient receptor potential vanilloid 1 (TRPV1) and cannabinoid 1 receptors in the brain [4, 5, 6].

What is the M367 Pill Used For?

The M367 White Pill is used for severe ongoing pain and should not be used for treating slight pain that might go away naturally. Since hydrocodone bitartrate is an opioid pain reliever, it has a high potential for being abused.

In fact, hydrocodone bitartrate with acetaminophen (M367) is a Schedule II controlled substance under The Controlled Substances Act of the Drug Enforcement Agency (DEA) in the US [7]. This means that the DEA recognizes that M367 has medical use, but classifies the drug as having a high potential for abuse and its abuse may lead to severe psychological or physical dependence. Other drugs in this category are Methadone, Oxycodone, Morphine or Fentanyl, which are well-known for their role in the opioid crisis.

For this reason, it is important to listen to your healthcare provider and take M367 with caution.

What are the side effects of the M367 Pills?

The side effects range from common ones, to more serious ones. The common side effects are:

  • drowsiness
  • dizziness
  • nausea and vomiting
  • Dry Mouth
  • Itching
  • Impaired Motor Skills
  • Constipation and Stomach Pain

The more serious side effects of M367 Pills include:

  • Seizures
  • Feeling like you might pass out,
  • Rapid heart rate (which could lead to heart failure),
  • Painful urination
  • Liver problems
  • Confusion.

Other side effects include allergic reactions that could potentially be lethal [2, 8, 9]. Additionally, it is important to keep in mind that hydrocodone, contained in the M367, is an opioid that can be lethal. Hydrocodone overdose can stop your breathing (respiratory depression), leading to death [10]. It is important to seek medical attention if you experience serious side effects while taking the M367 Pill.

Can you become addicted to the M367 Pill?

Yes, being addicted to the M367 pills is possible. Addiction can occur if the drug is used for a longer time period or in higher doses than prescribed [10]. You should always take the drug exactly as prescribed, and consult your doctor if you notice signs of addiction.

Since M367 pills are addictive opioids, they can cause opioid withdrawal symptoms. If you suddenly stop taking hydrocodone, you may experience withdrawal symptoms such as anxiety, trouble sleeping, or abdominal pain and stomach cramps.

Why are M367 pills addictive?

In general, opioids are highly addictive, because they bind to receptors in the brain to release dopamine, and this creates a temporary feeling of pleasure. If the opioid is taken for a longer time period, the brain reduces its natural dopamine production, and to achieve the same feeling of pleasure, higher or more frequent doses of the opioid are needed.

Are there any dangerous interactions with the M367 Pill?

The M367 Pill, especially hydrocodone, does have potentially dangerous interactions. For example, mixing the M367 Pill with alcohol can be extremely dangerous, and can lead to death. Additionally, mixing alcohol and acetaminophen, contained in M367, can cause damage to the liver.

Hydrocodone can also interact with other opioids, benzodiazepines, muscle relaxers, certain seizure drugs, certain HIV drugs, and many others [9]. It is important to take great care when combining M367 with other drugs, and it is essential that you consult a medical professional.

Counterfeit M367 Pills

There have been instances of counterfeit pills being sold. The DEA website contains images of fake Oxycodone, Adderall, and Xanax, and M367 is no exception. These counterfeit pills can be potentially dangerous - for example, they could be laced with fentanyl, an extremely strong and potentially dangerous opioid. It is vital that you obtain your medication from official sources like respectable pharmacies.

Nithishwer Mouroug Anand

Nithishwer Mouroug Anand

Nithish is a Doctoral Researcher in Computational Biochemistry at the University of Oxford. A physicist by training, he applies principles of thermodynamics and computational methods to investigate the interactions between drugs, proteins, and cell membranes. His expertise ranges from single-cell RNA sequencing and cancer genomics to utilizing free energy methods to understand protein biophysics.