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Neurological Disorders

Can Frontotemporal Dementia (FTD) Be Inherited?

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Frederika Malichová

Frederika Malichová

Neuroscientist at the University Of Cambridge.

Familial FTD

Yes, Frontotemporal dementia (FTD) can be inherited. In fact, it is highly heritable disease. Overall, around 40% if all the FTD cases are due to inherited mutations on one of these three genes: Chromosome 9 open reading frame 72 (C9orf72), Microtubule-associated protein tau (MAPT) or Progranulin (GRN). The genetic inheritance is equal for both sexes regardless of parental gender. Inherited form of FTD is called familial FTD. However, FTD can occur sporadically as well, without a known genetic cause.

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Frederika Malichová

Frederika Malichová

Frederika is a postgraduate researcher at the University of Cambridge, where she investigates new biomarkers for Frontotemporal Dementia and other tauopathies. Her research has been published at prestigious conferences such as the Alzheimer’s Association International Conference 2023. She obtained her BSc in Biomedical Sciences from UCL, where she worked closely with the UK Dementia Research Institute.