What is L-Theanine?
L-theanine is a major amino acid uniquely found in green tea and some mushrooms. It's a nonproteinogenic amino acid, meaning it doesn't contribute to the formation of proteins in the body [1, 2]. This compound is known for its potential health benefits and is often used as a supplement for its calming effects [3]. It can also be supplemented by taking pills or L-Theanine gummies
L-theanine has been reported as a relaxing agent, prompting scientific research on its pharmacology. It's suggested that L-theanine increases brain serotonin, dopamine, GABA levels, and has micromolar affinities for AMPA, Kainate, and NMDA receptors [1].
In addition to its calming effects, L-theanine has been shown to exert neuroprotective effects in animal models, possibly through its antagonistic effects on group 1 metabotrophic glutamate receptors. It's also suggested that L-theanine may improve learning and memory [1].
Furthermore, L-theanine exhibits strong antioxidant-like properties and contributes to the favorable umami taste sensation. It has been associated with improvements in brain and gastrointestinal function, cancer drug therapeutic efficacies, antihypertensive effects, and improved immune function [4].
L-theanine should not be confused L-Thyrosine
What is Melatonin?
Melatonin, also known as N-acetyl-5-methoxy tryptamine, is a hormone that is naturally produced by the human body, primarily by the pineal gland located in the brain [5, 6]. This hormone plays a crucial role in regulating the body's circadian rhythm, which is the internal clock that dictates sleep-wake cycles [5, 7].
Melatonin production increases in the evening, inducing sleepiness at night and promoting wakefulness during the day [6]. It is often referred to as the 'hormone of darkness' because its secretion is stimulated by darkness and inhibited by light [8, 9].
In addition to its role in sleep regulation, melatonin has been found to interact with more than 15 proteins, including receptors, enzymes, transporters, and other proteins, at varying concentrations [10]. It also has antioxidant properties and plays a role in the regulation of the cell cycle [6].
Melatonin is available as a dietary supplement and is often used to address sleep disorders, jet lag, and certain circadian rhythm disorders [5]. However, it's important to note that the National Institutes of Health’s National Center for Complementary and Integrative Health (NCCIH) states that there's not enough evidence to recommend melatonin as a treatment for chronic insomnia [5].
Is it safe to take Melatonin and L-theanine together?
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