The Safety of Combining L-Theanine and Adderall

In this article, we will take a close look at the potential effects and safety of combining L-Theanine, an amino acid found in green tea and mushrooms, and Adderall, a prescription medication used for treating ADHD and narcolepsy. We will delve into the individual properties of these substances and the importance of consulting with a healthcare provider before combining them.
Natasha Puttick

Natasha Puttick

Graduate medical student at Barts and London.

A blue image with text saying "L-Theanine and Adderall"

What is L-Theanine?

L-theanine is a major amino acid uniquely found in green tea and some mushrooms. It's a nonproteinogenic amino acid, meaning it doesn't contribute to the biosynthesis of proteins in the body. L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology [1].

L-theanine exhibits strong antioxidant-like properties and contributes to the favorable umami taste sensation. Several studies have reported that the consumption of this amino acid has many therapeutic effects, including improvements in brain and gastrointestinal function, cancer drug therapeutic efficacies, antihypertensive effects, and improved immune function [2].

L-theanine is also available in pill or tablet form and is said to help ease anxiety, stress, and reduce insomnia [3]. It can also be found in the form of L-Theanine Gummies.

What is Adderall?

Adderall is a prescription medication primarily used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy, a condition that causes excessive daytime sleepiness. It is a stimulant medication that contains two active drugs: amphetamine and dextroamphetamine. These active ingredients work by increasing the levels of certain neurotransmitters in the brain, specifically dopamine and norepinephrine, which help with focus, attention, and alertness.

Adderall comes in two forms: an immediate-release tablet and an extended-release capsule known as Adderall XR. The immediate-release form releases the drug into your body right away, while the extended-release form slowly releases the drug into your body over a longer period of time. It's important to note that Adderall XR is used to treat ADHD only and not narcolepsy [4, 5, 6].

Adderall is a controlled substance due to its potential for addiction and misuse. Therefore, it should only be taken under medical supervision and according to the prescribed dosage [7].

The Safety of Combining L-Theanine and Adderall

L-Theanine is an amino acid found in tea, and it's often used for its potential mood-enhancing and relaxation properties [4, 6]. Adderall, on the other hand, is a stimulant medication commonly prescribed for attention deficit hyperactivity disorder (ADHD) [5].

The safety of combining L-Theanine and Adderall is not explicitly addressed in available scientific studies. However, it's important to note that both substances have different effects on the brain. L-Theanine has been shown to improve cognitive performance and reduce anxiety [7, 6], while Adderall is a stimulant that can increase focus and decrease feelings of fatigue [5].


In the absence of direct evidence, it's crucial to consult with a healthcare provider before combining these substances. This is especially important because Adderall is a controlled substance, and its use should be closely monitored by a healthcare professional [8].


While L-Theanine and Adderall have been studied separately for their effects on cognitive performance and mood, there is no direct evidence regarding the safety of combining these two substances. Therefore, it's essential to consult with a healthcare provider before starting any new supplement regimen, especially when it involves a controlled substance like Adderall.

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Natasha Puttick

Natasha Puttick

Natasha is a medical student at Barts and the London school of Medicine and Dentistry, with an interest in the social determinants of health. She graduated from the University of Oxford with a BA in Human Sciences and has obtained two publications. Her most recent work investigating clinical vaccine trials has been published in BMJ Public Health.