Main takeaway: portobello mushrooms are safe to eat
There is extremely limited evidence demonstrating any adverse effects of consuming portobello mushrooms. While uncooked portobello mushrooms may contain a mycotoxin called agaritine, the quantity of this compound in a typical serving of mushrooms is relatively low and the molecule breaks down readily when mushrooms are cooked. Furthermore, human toxicological studies on the effects of agaritine have not been conducted, which limits the generalizability of scientific claims. To date, studies claiming that agaritine may be carcinogenic have been conducted in animal models using pure agaritine extract at extremely high concentrations. All this being said, eating portobello mushrooms does not have zero risk: for example, individuals with fungal allergies or high uric acid levels may want to be mindful of their portobello consumption.
Portobello mushrooms
What are the health benefits of portobello mushrooms?
Portobello mushrooms have a fairly favorable nutritional profile. They are high in dietary fiber and contain essential vitamins, minerals, amino acids, and antioxidants [2].
Specifically, portobello mushrooms are high in selenium, which has been linked to improved immune function and protection against oxidative stress [3]. For vegetarians and vegans, portobello mushrooms are also a valuable source of plant-based protein, B vitamins, and vitamin D [2].
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