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Periodontitis can contribute to Alzheimer's Disease (AD) through several mechanisms. One mechanism is the direct translocation of periodontal bacteria from the oral cavity to the brain, which can cause neuroinflammation and AD-like pathology 21. Another mechanism is through the systemic inflammation caused by periodontitis. This "low-grade systemic inflammation" can affect the inflammatory state of the central nervous system, contributing to the onset and progression of AD 43. Furthermore, periodontitis can lead to an increased β-amyloid burden, a hallmark of AD, and cognitive disabilities later in life 5. Lastly, periodontal pathogens can damage the blood-brain barrier, which may give rise to AD pathology 2. However, the exact molecular mechanisms are not fully understood and further research is needed 15.

1
Lamphere et al. (2023)
2
Kouki et al. (2022)
3
Kamer et al. (2008)
4
Gurav (2015)
5
Sadrameli et al. (2021)