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BPC-157 vs TB-500: Differences and Similarities

In this article, we will provide further insight into two peptides which have recently sparked notable interest: BPC-157 and TB-500. We will discuss how their functioning aims to enhance health benefits and medical uses. We will also compare the differences and similarities between these two peptides, and discuss the ethics of their use.

Greta Daniskova

Author - Greta Daniskova

Greta is a BSc Biomedical Science student at the University of Westminster, London.

Greta used MediSearch to find sources for this blog.
MediSearch gives instant answers to medical questions based on 30 million scientific articles.

Key Differences Between BPC-157 and TB-500

BPC-157 and TB-500 are both peptides known for their healing properties, but they function differently. BPC-157, a gastric peptide, has been shown to accelerate wound healing, reduce inflammation, and promote angiogenesis, the formation of new blood vessels. On the other hand, TB-500, a synthetic version of a protein found in the human body, is primarily known for its ability to promote muscle and skin tissue growth and repair, and reduce inflammation.

BPC-157: What is it, and what does it do?

What is BPC-157?

BPC-157 is a peptide which consists of a chain of 15 amino acids. This peptide has been intensively studied for its healing capacities, particularly related to angiogenesis, i.e. its ability to create new blood vessels [1]. It has been observed that BPC-157 increases the density of vessels, restores blood supply to ischaemic muscles and can up-regulate VEGFR2 (vascular endothelial growth factor receptor 2). These are just a couple of reasons why this peptide has been claimed to have a plethora of healing abilities [1].

What are the applications of BPC-157?

Applications of BPC-157

A study found that BPC-157 can be therapeutically used as a remedy for inflammatory bowel disease and wound healing and found no toxic side effects [2]. Not only has it been demonstrated to be a potent pro-angiogenic factor, but it has also been shown to be an anti-inflammatory, cytoprotective, and endothelial-protective agent that could counteract several well-established side effects of prolonged NSAID (Non-steroidal anti-inflammatory drugs) use [2].

BPC-157 has been proposed as a potential treatment of physiologically based illnesses that disproportionately affect certain patient populations, such as the COVID-19 illness, as it improves vascular integrity and immune response, reduces the pro-inflammatory profile, has an anti-inflammatory effect, and reduces the lethality of critical COVID-19 illnesses [3].

However, it is important to note that BPC 157 is an experimental drug, with most studies conducted on small rodents. Further research is needed to validate the safety of BPC 157.

TB-500: What is it, and what does it do?

What is TB-500?

TB-500, which can be derived as Thymosin Beta-4, is a synthetic peptide. It aims to enhance wound healing, physical ability, and stamina. Furthermore, it plays a pivotal role in preserving, regenerating, and remodelling impaired tissues. TB-500 is utilized to reinforce wound healing, decrease tissue inflammation, and minimize tissue damage.

TB-500: What are the applications of TB-500?

Wound healing is one of the main postulated uses of TB-500. That’s because the active region of the thymosin β (4) protein governs its activity (i.e., its ability to bind to actin, drive cell migration, and promote wound healing). So, TB-500 is alleged to enhance endothelial cell differentiation, promote angiogenesis in dermal tissues, and increase both keratinocyte migration and collagen deposition while also reducing inflammation [4].

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