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Can Ozempic Cause Personality Changes?

In this article, we will take a close look at the medication Ozempic (semaglutide) and its potential side effects. We will specifically focus on whether Ozempic can cause personality changes and discuss other common side effects, such as dysgeusia and hypoglycemia. We will also address the importance of consulting with a healthcare provider if significant mood or behavior changes occur while taking this medication.

Jakub Gwiazdecki

Author - Jakub Gwiazdecki

Fifth year medical student at the Medical Faculty of Comenius University in Bratislava.

Jakub used MediSearch to find sources for this blog.
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Can Ozempic cause personality changes?

Currently, studies show no evidence of Ozempic directly causing personality changes.

However, some side effects of this medication used primarily for diabetes are similar to personality changes. Some patients who take Ozempic can experience mood and behavior changes. These adverse effects can arise due to physical or psychological changes during treatment.

A person taking Ozempic can change behavior, for example, due to changes in taste. This side effect is not common [1, 2], but it can significantly affect how a person approaches and enjoys food.

Another change that can lead to changes in behavior is the phenomenon called “Ozempic face” [3]. It is a change in the physical appearance of the face due to a fast loss of fat tissue. The skin on the face becomes sagging [3]. Such a change can make a person feel uncomfortable with their look.

What other side effects does Ozempic have?

The most common side effects of Ozempic are:

  • nausea,
  • vomiting,
  • constipation,
  • abdominal pain,
  • diarrhea [4]. These symptoms typically range from mild to moderate and can last even a few weeks [4].

The use of Ozempic with other diabetes drugs can contribute to the development of a low blood sugar state [4].

Other adverse effects include taste alteration. For instance, abnormal mouth tastes, such as metallic, sour, or bitter tastes, can occur [1, 2].

Also, the use of Ozempic increases the risk of thyroid cancer [5]. Rarely, Ozempic therapy can lead to diabetic retinopathy, pancreatitis, kidney problems, and gallbladder disease, such as gallstones and cholecystitis [5].

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Although rare, some people can have an allergic reaction to Ozempic. This reaction can result in rashes, itchiness, and swelling of the lips, hands, and feet. However, in some cases, the allergy can cause swelling of the mouth, tongue, and throat, leading to breathing problems [6]. P$

Should I see a doctor when I have personality changes with Ozempic?

You should talk to your doctor if you notice personality changes while on Ozempic. It is crucial as such changes can indicate an underlying mental health condition and should be addressed [7].

Among some of the signs of personality changes are aggression, frequent mood swings, no motivation, and irritability [2]. Experiencing personality changes can be triggered by medications [7].

Generally, Ozempic is not known to change personality. However, everyone's reaction to a drug is different. Therefore, psychological changes with Ozempic should be followed by healthcare professionals to exclude the possibility that the drug causes them [3].

During your consultation, the doctor can prescribe tests to determine what is happening inside your body. Typical tests include glucose levels, hormone profiles, and complete blood counts. Sometimes, the physician can order an imaging study like an MRI [7].

When all the internal factors are in order, the doctor will refer you to a mental healthcare professional. The following checks with the mental expert will further investigate the origin of your personality changes [7].

Which drugs typically change your personality?

Ozempic is not known to change the personality. The drugs that most commonly change affect your personality are:

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