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Can Ritalin Cause Headaches?

In this article, we will take a close look at Ritalin, a central nervous system stimulant used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. We will explain its mechanism of action, indications, and potential side effects, including the possibility of headaches.

Jakub Gwiazdecki

Author - Jakub Gwiazdecki

Fifth year medical student at the Medical Faculty of Comenius University in Bratislava.

Jakub used MediSearch to find sources for this blog.
MediSearch gives instant answers to medical questions based on 30 million scientific articles.

Can Ritalin cause headaches?

Yes, Ritalin can cause headaches [1]. The types of headaches Ritalin can cause include throbbing, dull, and sharp headaches, or pressure pains [2].

Although headaches after Ritalin are a common side effect, not everyone will experience them [2].

What should you do against headaches from Ritalin?

When you experience headaches after Ritalin, try the usual over-the-counter headache drugs. Medication like Tylenol and Advil can be useful to counter the pain [2].

However, remember not to take these drugs longer than 15 days per month [3].

You should consult your doctor if you have a headache that lasts longer.

General strategies for coping with headaches include staying hydrated [4], sleeping enough, eating healthy, and engaging in physical activity [5].

In some people, taking caffeine can help to increase the effectiveness of the over-the-counter painkillers [6].

What is Ritalin?

Ritalin's active substance is methylphenidate, a central nervous system stimulant that helps with hyperactivity and impulse control [7].

Ritalin can be part of the treatment of attention deficit hyperactivity disorder, attention deficit disorder, and narcolepsy [7, 8].

Methylphenidate modulates the neurotransmitter concentrations in the brain, improving concentration, attentiveness, and listening skills [8,9].

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Ritalin is a brain stimulant with addictive potential. Therefore, you should use it always under a doctor’s supervision [8].

How does Ritalin work?

Ritalin is a neurotransmitter concentration modulator. One main way it influences the brain is by blocking the reuptake of norepinephrine and dopamine in the presynaptic membranes [10].

The inhibition of the reuptake of these neurotransmitters leads to an increase in their concentration in the synapse [10].

The higher concentration of norepinephrine and dopamine in the synapse enhances the signal quality and, with it, attention [10].

Ritalin also affects the N-methyl-D-aspartate (NMDA) [11] and the quisqualate (AMPA) receptors [12].

The NMDA receptor increases synaptic plasticity, while the AMPA receptor increases glutamate signaling [12, 11].

By activating these two receptors, Ritalin enhances the glutamate-linked functions of the brain, such as learning, memory, and cognitive functions [13].

What are the side effects of Ritalin?

The side effects of Ritalin can vary from mild to serious. One of the most common side effects is abdominal pain [2].

Other adverse effects of Ritalin include

Ritalin can, in rare cases, also cause an allergy. The allergic reaction to Ritalin can present with rashes, facial, lips, or tongue swelling, and difficulty breathing [2].

Severe allergic reactions are emergencies. In such cases, you should immediately seek medical attention [2].

Among other more severe side effects of Ritalin are heart palpitations, hypertension, anxieties, mania, and circulation disturbances, as Raynaud’s phenomenon [2].

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