Enclomiphene vs hCG: Overview
Enclomiphene
Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. It is the trans-stereoisomer of clomiphene citrate, a drug that has been widely prescribed for several decades for the treatment of female ovulatory dysfunction. Enclomiphene has the potential to increase serum testosterone levels in men with secondary hypogonadism by restoring physiological endogenous testosterone secretion while maintaining testicular volume and, potentially, spermatogenesis [1].
Human Chorionic Gonadotropin (hCG)
On the other hand, Human Chorionic Gonadotropin (hCG) is a hormone produced by the placenta after implantation. It is commonly used in fertility treatments for both men and women. In men, hCG mimics the luteinizing hormone (LH) produced by the pituitary gland, stimulating the testes to produce testosterone and sperm. It is often used in combination with other fertility drugs to increase the chances of conception.
Enclomiphene vs hCG: Uses
Human Chorionic Gonadotropin (hCG) and Enclomiphene are two substances that have been studied for their potential benefits in various medical contexts.
Uses of hCG
hCG is primarily known for its role in pregnancy. It is the primary embryonic signal in primates, associated with corpus luteum rescue and progesterone production. However, hCG has been found to have several extragonadal actions. It mediates multiple placental, uterine, and fetal functions, including the development of syncytiotrophoblast cells, mitotic growth and differentiation of the endometrium, localized suppression of the maternal immune system, modulation of uterine morphology and gene expression, and coordination of intricate signal transduction between the endometrium [2]. hCG has also been used to predict preeclampsia, determine the risk of Down's syndrome and gestational trophoblastic disease, relax myometrial contractility, and prevent recurrent miscarriages [2].
Uses of Enclomiphene
Enclomiphene, on the other hand, is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. It has been found to increase serum testosterone levels in men with secondary hypogonadism by restoring physiological endogenous testosterone secretion while maintaining testicular volume and potentially spermatogenesis [1]. Enclomiphene citrate has also been shown to increase serum testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels, without negatively impacting semen parameters [3]. This makes it a potential treatment for men in whom testosterone therapy is not a suitable option [3]. Furthermore, enclomiphene citrate treatment has been associated with maintaining sperm concentrations in the normal range [4].
Enclomiphene vs hCG: Side effects
Side effects of Enclomiphene
...
It's important to note that long-term use of clomiphene may increase the risk of ovarian cancer, and it should not be used for more than about six cycles [5].
Side effects of hCG
Human chorionic gonadotropin (HCG) is a hormone that can be used in combination with other medications for the treatment of certain conditions, such as polycystic ovarian syndrome. Side effects of HCG are not extensively documented in the provided studies. However, one study noted that the combined use of HCG and clomiphene in the treatment of polycystic ovarian syndrome resulted in a total incidence of adverse reactions of 6.67%, including symptoms such as nausea, vomiting, anorexia, and liver dysfunction [6].
As with any medication, it's important to consult with a healthcare provider to understand the potential risks and benefits before starting treatment.