Hexarelin: A Comprehensive Overview

In this article, we will take a close look at Hexarelin, a synthetic growth hormone-releasing peptide. We will explore its potential benefits, including its cardioprotective effects and its potential for muscle building, as well as the potential risks associated with its use.
Natasha Puttick

Natasha Puttick

Graduate medical student at Barts and London.

A blue image with text saying "Hexarelin"

What is Hexarelin?

Hexarelin is a synthetic growth hormone-releasing peptide. It is chemically more stable and functionally more potent than its natural analog, ghrelin. Hexarelin can bind to and activate the growth hormone secretagogue receptor (GHSR) in the brain, similar to ghrelin. However, it also has direct cardiovascular actions beyond growth hormone release and neuroendocrine effects, due to the peripheral distribution of GHSR in the heart and blood vessels. Hexarelin has been shown to have cardioprotective effects and may be a promising therapeutic agent for some cardiovascular conditions [1].

To see how Hexarelin compares to other similar substances, take a look at our blog comparing hexarelin vs ipamorelin.

What are Hexarelin’s cardio-protective effects?

There are several mechanisms through which hexarelin may offer cardioprotective effects. Studies have shown that hexarelin can protect cardiomyocytes from ischemia/reperfusion (I/R) injury, a common cause of heart damage during heart attacks. This protective effect is achieved through the modification of the IL-1 signalling pathway via the activation of cardiac GHSR1a receptors [1].

Hexarelin has also been found to attenuate atherosclerosis, a condition characterised by the hardening and narrowing of the arteries. This is achieved by modulating the circulatory lipids (fats) profile [2].

In addition, hexarelin has been shown to reduce cardiac fibrosis, a condition characterised by the thickening and scarring of the heart tissue, though this has only been tested in spontaneously hypertensive rats. This is achieved by decreasing collagen synthesis and accelerating collagen degradation via regulation of MMPs/TIMP (matrix metalloproteinases) [3].

Hexarelin also has potential neuroprotective effects. It has been shown to inhibit hydrogen peroxide-induced apoptosis (death) in Neuro-2A cells [4].

Lastly, hexarelin has been shown to accelerate growth in short children [5].

Potential risks of Hexarelin

Risks of Hexarelin include its lack of efficacy, impact on the immune system and interference with other medicines. It's important to note that hexarelin has a low oral bioavailability, meaning it may not be as effective when taken orally [6],[7]. Additionally, while not specific to hexarelin, drugs with similar properties may lower the body's resistance to infections and affect the number of white blood cells and platelets, increasing the risk of infection and bleeding [5]. Therefore, regular check-ups are necessary to monitor the drug's effects and potential unwanted side effects [8]. It's also important to consider individual health conditions that may affect the use of such medicines

Hexarelin and muscle building

There is not a sufficient number of studies that directly address the use of hexarelin for muscle building. However, they do provide some insights into the effects of hexarelin on growth hormone (GH) release, which could potentially have implications for muscle growth.

Hexarelin is a synthetic growth hormone-releasing peptide that has been shown to stimulate the release of GH in a dose-dependent manner [9]. GH is known to play a key role in muscle growth and development, so it's possible that hexarelin could indirectly contribute to muscle building by increasing GH levels. However, more research would be needed to confirm this.

It's also worth noting that the effects of hexarelin on GH release appear to diminish over time with long-term use [10]. This could potentially limit its effectiveness for muscle building over the long term.

In conclusion, while hexarelin does stimulate the release of GH, which is involved in muscle growth, there is not enough evidence to definitively say that it can be used for muscle building. More research is needed in this area.


While Hexarellin may have benefits for growth and muscle building, the evidence does not strongly support its use as few comprehensive studies have been done in humans. More research is needed to fully understand the potential benefits and limitations of Hexarellin in this context.

Crucially if you are thinking of taking these supplements, please consider the risks carefully and discuss with a licensed medical practitioner as they are often under-researched and the side effects ill understood. Additionally, some peptides are illegal to purchase in certain countries.

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Natasha Puttick

Natasha Puttick

Natasha is a medical student at Barts and the London school of Medicine and Dentistry, with an interest in the social determinants of health. She graduated from the University of Oxford with a BA in Human Sciences and has obtained two publications. Her most recent work investigating clinical vaccine trials has been published in BMJ Public Health.