LGD-4033 vs RAD-140: An Overview
LGD-4033
Ligandrol (LGD-4033) is a selective androgen receptor modulator (SARMs). SARMs are a class of therapeutic compounds that have similar effects to anabolic steroids but with reduced androgenic properties [1, 2, 3]. Ligandrol was first included in the World Anti-Doping Agency (WADA) Prohibited List 2018 [4].
RAD-140
RAD-140 (Testolone), is another selective androgen receptor modulator (SARM) that has gained popularity among athletes and bodybuilders as a performance-enhancing substance. It is not approved for medical use but has been researched for potential therapeutic uses.
RAD-140 has been abused in sporting competitions, and WADA prohibits its use for athletes at all times. In fact, not much is known about the metabolism and elimination behavior of RAD-140 in humans, and it is still being studied. In one study, six micro-dose excretion studies with five adult male volunteers each were conducted, and urine samples were analysed utilising LC-HRMS/MS to investigate RAD140's elimination profiles [5].
In summary, while both Ligandrol and RAD140 are SARMs with potential for abuse in sports, some differences in their metabolism and elimination profiles are relevant for doping control purposes. More research is needed to characterise their effects and risks fully.
LGD-4033 vs RAD-140: Uses
Uses of LGD-4033
Ligandrol (LGD-4033) is a selective androgen receptor modulator (SARM). Its potential uses include:
Doping in sports
Ligandrol has been used in sports to improve muscle tissue. However, the World Anti-Doping Agency (WADA) prohibits Ligandrol. [2, 6]
Muscle growth promotion
Ligandrol is often misused by amateur athletes to promote muscle growth. However, Ligandrol has also been investigated as a potential treatment for disease-induced loss of muscle mass.
Bone health (Treatment of osteoporosis)
A study in ovariectomized rats found that a high dose of 3 mg/kg Ligandrol increased trabecular number in the femur (38 ± 8 vs 35 ± 7) compared to untreated rats, indicating some improvement in bone structure. However, it did not enhance biomechanical properties, and the dose had side effects.[6]
Uses of RAD-140
As discussed before, RAD140 is another SARM that athletes have abused to enhance performance. [5]
Anabolic effects
As a SARM, RAD140 is designed to have anabolic effects on muscle and bone tissue while minimizing androgenic effects on other tissues
Workout supplement
It is easily purchased online as a workout supplement, particularly popular among young males. However, it's crucial to note that RAD140 is not FDA-approved for human use, and its safety profile is not well-established. Serious adverse effects have been reported, as we will shortly discuss.
Potential neuroprotective effects
RAD-140 has shown neuroprotective properties in cultured rat neurons and male rat brains, which may be relevant to Alzheimer's disease and related neurodegenerative conditions [8].
Both Ligandrol and RAD140 are investigational SARMs that have been misused for doping in sports. While they may have some potential therapeutic uses, such as in osteoporosis for Ligandrol, more studies are required to establish their efficacy and safety. Abuse of these substances by athletes remains a challenge for anti-doping authorities.
Side effects of LGD-4033 and RAD-140
Ligandrol (LGD-4033): A 32-year-old man developed severe drug-induced liver injury after using Ligandrol. Other side effects include Suppression of total testosterone (62.3% decrease), free testosterone (85.7% decrease), and sex hormone-binding globulin (79.6% decrease), or possible suppression of follicle-stimulating hormone.
In a rat study, high doses of Ligandrol (3 mg/kg) increased serum phosphorus levels, uterus weight, and heart weight compared to the control group.
RAD-140:
- Myopericarditis: A case report describes a 16-year-old boy who developed myopericarditis following the first dose of Testolone [8]
- Suppression of natural testosterone production
- Liver toxicity
- Cardiovascular issues
- Mood changes or aggression
It's important to note that the FDA disapproves SARMs for human use. They are considered experimental drugs and are often sold illegally as supplements. Using them can be dangerous due to the lack of long-term safety data and the potential for serious side effects.
If you experience any adverse effects while using SARMs, stop taking them immediately and consult with a healthcare professional. Contact the FDA's MedWatch Adverse Event Reporting program to report a severe side effect. [7]