Adderall: Indications and Mechanisms
Adderall is a combination of two stimulants, amphetamine and dextroamphetamine. It is used to treat ADHD by stimulating the central nervous system and increasing the levels of norepinephrine and dopamine, two critical hormones regulating cognitive functions and activity [1].
Dopamine and Addiction
Dopamine is also responsible for developing addictions because it increases wanting for items, making Adderall a tightly controlled prescription drug.
Adderall helps individuals with ADHD improve focus and concentration and manage hyperactivity. It is often prescribed as part of a comprehensive treatment program that may also include psychological or behavioural therapy, for example, Cognitive Behavioural Therapy. The dose of Adderall is gradually increased over time, so it is important to pay attention to your symptoms and discuss them with your healthcare professional.
In people with narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and falling asleep throughout the day, Adderall helps increase wakefulness and alertness during the day [1, 2]. This is thanks to the effects of Adderall on norepinephrine, which works by increasing excitation in the pre-frontal part of the brain. Increasing excitation in the prefrontal brain increases one’s executive function and control. However, Adderall does not help with learning and is an ineffective study aid.
What Is The Dosage of Adderall?
Adderall is usually taken in the morning, which is the best time of day for improving focus, performance, and cognitive function.
The specific dose of Adderall depends on the formulation you are taking. As a guideline:[3]
- Adderal XR: Adderall extended-release capsules. For adults, it is recommended to take up to 20mg in the morning, whereas in children, this should not exceed 10mg.
- Adderall tablets: This immediate-release formula should be taken at only 10mg/day in adults and 5mg daily in children under 12.
- Adderall tables for narcolepsy: For narcolepsy treatment, adults should take no more than 10mg a day, and children should not exceed 5mg a day.
The precise dose of Adderall you should take must be discussed with your healthcare provider.
Six Signs Your Adderall Dose Is Too Low
Watch out for these signs and bring them up at your next medical appointment to determine if you need a higher dose of Adderall.
1. You struggle to maintain focus
Inability to focus is one of the hallmark symptoms of ADHD that Adderall targets. This is because attention is controlled by the prefrontal cortex, which is disrupted by neurotransmitter and neurobiological changes in ADHD [4, 5].
2. Impulsivity
Impulsive behaviour is another sign of ADHD, which is distinct from compulsive behaviour observed in obsessive compulsive disorder (OCD) [6]. Impulses, such as impulsive language or movements, are also regulated by the prefrontal cortex. Hence a dose of Adderall that is too low may not be sufficiently effective to activate the prefrontal cortex for impulse inhibition.
3. Hyperactivity
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