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Why Am I Gaining Weight On Ozempic?

In this article, we will take a close look at Ozempic, a medication primarily used to treat type 2 diabetes, and its effects on weight. We will explain why some people might experience weight gain while using this drug despite its appetite-suppressing properties. We will also discuss the importance of consulting a healthcare provider when experiencing unexpected weight changes.

Jakub Gwiazdecki

Author - Jakub Gwiazdecki

Fifth year medical student at the Medical Faculty of Comenius University in Bratislava.

Jakub used MediSearch to find sources for this blog.
MediSearch gives instant answers to medical questions based on 30 million scientific articles.

Why am I gaining weight on Ozempic?

Ozempic is a medication primarily used to treat type 2 diabetes. Its main active compound is semaglutide. In many people, one of the side effects of Ozempic is weight loss, but not everyone who takes Ozempic will lose weight. Nearly 14% of patients treated show no changes in weight. There is even a chance tof gaining weight while taking Ozempic [1, 2].

As Ozempic mimics the natural hormone GLP-1, one of its effects is delayed stomach emptying. The prolonged time food stays in the stomach decreases appetite and calorie intake [3].

A lower appetite can effectively decrease body weight. However, whether your weight actually decreases depends on diet and physical activity, and the duration of treatment. [3]. Another critical factor impacting the weight changes during Ozempic therapy is how the body responds to the medication [3].

It is possible to gain weight on Ozempic. One reason for this can be the influence of other medications you take, or a recent change in diet or exercise. You may also need a dose adjustment or even a different medication.

Should I limit my diet when taking Ozempic?

Generally, there are no specific dietary restrictions when taking Ozempic. However, to increase the effectiveness and outcome of the therapy, maintain a balanced diet. Also, regular exercise will help you with the effects.

A balanced diet that supports weight loss and blood sugar control with Ozempic could include many fruits, vegetables, lean proteins, and whole grains. You should limit processed food and sugary drinks.

Can Ozempic not work on me?

It is possible that Ozempic is not working on you. Generally, the medication is effective in most people. However, some people do not respond to it [1, 2].

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Should I see a doctor when I gain weight on Ozempic?

You should see your doctor when you notice a weight gain when taking Ozempic. Your doctor will investigate why you are not responding to the therapy. Clinical trials have shown that some people may not lose weight during Ozempic therapy, and some may even gain weight [1, 2].

Weight gain on Ozempic can indicate your body is not responding to the medication. During a consultation, your doctor may suggest a diet or exercise adjustment [3]. These changes may be effective and lead to weight loss.

If it turns out that you are not responding to Ozempic, the doctor may change your medication.

See a doctor soon when you gain weight on Ozempic and have neck lumps or swallowing problems. These changes have to be followed as they may be signs of thyroid cancer. Ozempic increases the risk of this cancer [4].

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