Overview: What Are Ibuprofen and Metformin?
Ibuprofen
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely used to relieve fever and mild to severe pain [1]. It blocks prostaglandin, a natural compound that sends pain signals [1]. Ibuprofen is also a potential inhibitor for cyclooxygenase enzymes (COX-1 and COX-2) [2].
Ibuprofen is commonly used to treat conditions such as headaches, menstrual cramps, arthritis, muscle aches, and dental pain [1]. It also treats inflammation, pain, and stiffness in joint conditions like rheumatoid arthritis, osteoarthritis, and primary dysmenorrhea (painful menstrual periods) [3].
Metformin
Metformin is a widely used drug primarily prescribed to manage type 2 diabetes. It has been in practical use for over six decades and continues to be the preferred drug for newly diagnosed type 2 diabetes mellitus [4, 5]. Metformin reduces glucose production in the liver, decreases insulin resistance, and increases insulin sensitivity, thereby effectively lowering blood glucose levels [6, 7].
Beyond its primary use in managing type 2 diabetes, Metformin has been found to have several other clinical applications. It is used in the treatment of polycystic ovarian syndrome and gestational diabetes and as an adjunct therapy in type 1 diabetes. It is also used in prediabetes to prevent the progression to type 2 diabetes [8].
Besides these established uses, ongoing research is exploring the potential of metformin in preventing various diseases. These include cancer, Alzheimer's disease, and metabolic dysfunction-associated steatotic liver disease. Metformin is also being investigated for its potential in promoting healthy ageing [8].
However, it's important to note that while metformin has shown potential in treating various conditions, more extensive research is needed to confirm these additional benefits [9].
Can you take Ibuprofen with Metformin?
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