What is L-Tryptophan?
L-tryptophan is an essential amino acid, meaning it cannot be produced naturally by the body and must be obtained from the diet. It is one of the tryptophan isomers, the other being D-tryptophan. It is unique among amino acids as it contains an indole ring, a structure that contributes to producing various bioactive molecules in the body [1]. These include serotonin, melatonin and vitamin B6 [2].
Increasing levels of l-tryptophan, for example, using dietary supplements, can increase serotonin levels with minimal risk of side effects, including serotonin syndrome. This has led to the use of l-tryptophan supplements as a natural antidepressant and aid in improving sleep quality [9, [1].
L-tryptophan is widely used in the food, medicine, and feed sectors. It can be produced through fermentation and engineered bacteria [3].
L-Tryptophan in Dogs
L-tryptophan, an essential amino acid, plays a significant role in dogs' health and behaviour. It is a precursor to important molecules such as serotonin, melatonin, and niacin, which are crucial for physiological functions and canine health [4].
The requirement for tryptophan in dogs' diets varies with age and breed. For instance, the tryptophan requirement for maximal weight gain in dogs aged 6 to 14 weeks was found to be 0.15% [5].
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