What is THC?
Tetrahydrocannabinol, commonly known as THC, is the primary psychoactive compound found in the cannabis plant. This compound is responsible for the "high" sensation often associated with cannabis use [1]. THC is produced in the cannabis plant as tetrahydrocannabinolic acid (THCA). When the plant is heated or burned, THCA decarboxylates to form THC [2].
THC can be consumed in several ways, including smoking cannabis, and it's also available in oils, edibles, tinctures, capsules, and more [1]. The effects of THC are mediated through the endocannabinoid system (ECS), which promotes a positive energy balance through the stimulation of appetite and shifting homeostatic mechanisms toward energy storage [3].
The psychoactive actions of THC are primarily mediated by the cannabinoid receptor CB1 [4]. THC's effects can include sedation, euphoria, relaxation, and loss of social inhibition. However, higher doses can lead to adverse effects such as fear, distrust, a profound state of unease, hallucinations, ataxia, stupor, and seizures [5].
Microdosing on THC: What does it mean?
What is microdosing?
Microdosing refers to the practice of consuming tiny portions of substances, often psychedelic, in an attempt to enhance cognitive abilities and productivity [6]. The term is most commonly associated with the use of psychedelic substances such as lysergic acid diethylamide (LSD) and psilocybin-containing mushrooms, but it can also apply to other substances [7, 8].
A microdose is typically 1/10 to 1/20 of a normal dose or 10 to 20 micrograms [6]. The goal of microdosing is to achieve the positive effects of the substance, such as increased focus, energy, and emotional balance, without experiencing adverse effects, such as hallucinations and other extreme experiential side effects [6].
Microdosing has recently gained popularity as an experimental method for individuals to potentially enhance their productivity and state of mind [6, 7]. However, it's important to note that while there are anecdotal reports of benefits, scientific research on microdosing is still emerging, and more studies are needed to fully understand its effects and potential risks [7, 9].
Benefits of microdosing THC?
Microdosing THC, the active component of cannabis, has shown potential therapeutic benefits in various medical conditions. One of the key benefits is its potential as an antiemetic and appetite stimulant in debilitating diseases such as cancer, AIDS, and multiple sclerosis [10].
Another advantage of microdosing THC is its potential as an analgesic. It can help manage pain, making it a potential alternative to traditional pain medications.
Side effects of microdosing THC?
Microdosing THC, the primary psychoactive compound in cannabis, can still lead to a variety of side effects. These effects can vary from person to person and often depend on the dosage and the individual's tolerance.
One common side effect is anxiety. Some individuals may experience heightened feelings of worry or unease, mainly if they are new to cannabis use or if they consume a strain high in THC [11, 12].
Dry mouth is another frequently reported side effect. This can lead to discomfort and increased thirst [11, 12].
Increased heart rate is also a common side effect of THC use. This can be more pronounced in higher doses or in individuals who are new to cannabis [11, 12, 13].
Memory loss, particularly short-term memory loss, is another potential side effect. This can affect learning and decision-making abilities [11, 12, 14].
Some individuals may experience red eyes after consuming THC. This temporary side effect typically resolves as the high wears off [11, 15].
Slowed reaction times can also impair motor coordination and potentially make driving unsafe [11, 12, 15].
In rare cases, high doses of cannabis can cause hallucinations, paranoia, and panic attacks. These experiences are temporary and disappear as the high wears off [11, 12].
Lastly, nausea and vomiting can occur, particularly in individuals who consume high doses of THC or who are new to cannabis use [11, 12].
It's important to note that these side effects are dose-dependent and are more likely to occur with larger doses and with inexperienced cannabis users [13].