What is Tirzepatide?
Tirzepatide (TZP) is a dual GIP and GLP-1 receptor agonist that has shown promise in treating type 2 diabetes mellitus. It controls hyperglycemia, stimulates insulin secretion, and promotes weight loss. The drug is highly effective, surpassing insulin and GLP-1 in its efficacy. It is currently being studied for its safety and efficacy in treating type 2 diabetes, with results revealing significant reductions in HbA1c and weight across its various doses [1].
Microdosing Tirzepatide: What does it mean?
What is microdosing?
Microdosing refers to the practice of consuming tiny portions of substances, often psychedelic, in an attempt to enhance cognitive abilities and productivity. Microdosing has gained popularity recently through individuals who seeking to improve their state of mind and productivity [2,3].
It's important to note that while there are anecdotal reports of the benefits of microdosing, such as improved mood and focus, the scientific literature on this practice is still limited, and more research is needed to confirm these benefits [4, 5, 6].
Benefits of microdosing Tirzepatide
Blood Glucose and Weight Management: Tirzepatide has greatly improved blood sugar control and weight management. Clinical trials show that it lowers HbA1c levels (a measure of long-term blood sugar) and supports weight loss, all while being well-tolerated by patients.[7].
Lipid Profile Improvement: Tirzepatide has also been shown to lower triglycerides (fat in the blood) and raise good cholesterol (HDL). This combination makes it a promising option for people with type 2 diabetes and obesity, as it not only helps manage blood sugar but also supports weight loss and healthier blood fat levels [8].
Cardiovascular benefits: Along with these benefits, Tirzepatide has shown cardiovascular safety. Studies suggest that using Tirzepatide doesn’t raise the risk of major heart-related events (MACE), making it a safer choice for people with type 2 diabetes who are at risk of heart disease [8, 9].
Additionally, Tirzepatide has shown promise in enhancing insulin sensitivity and supporting beta-cell function, both of which are essential for managing type 2 diabetes. This makes Tirzepatide a potentially helpful treatment for early-stage type 2 diabetes [10, 11].
Neuroprotective Effects: Tirzepatide has shown potential neuroprotective effects in Alzheimer's disease model mice, indicating its potential use in managing neurodegenerative diseases [12].
Side effects of Tirzepatide
Tirzepatide has been associated with a range of side effects.
Abdominal pain: The most common ones include abdominal pain, which can be discomforting for the patient. This is often accompanied by burping, a symptom that can be quite bothersome for some individuals [13].
Constipation: Constipation is another common side effect of Tirzepatide, which can lead to discomfort and bloating. On the other hand, some patients may experience diarrhoea, which can lead to dehydration if not properly managed [13].
Indigestion: Dyspepsia, or indigestion, is another side effect that can cause discomfort in the upper abdomen. Fatigue is also common, affecting a person's daily activities and overall quality of life [13].
Gastroesophageal reflux disease: Gastroesophageal reflux disease (GERD) a condition where stomach acid frequently flows back into the tube connecting your mouth and stomach (oesophagus), is another side effect. This can cause symptoms such as heartburn and acid reflux [13].
Hair loss and Hypersensitivity reactions: Hair loss has also been reported, which can be distressing for some individuals. Hypersensitivity reactions, including skin rashes, itching, and swelling, are also possible [13].
Injection site reactions and nausea: Reactions at the site of injection which can include pain, redness, and swelling at the site of the injection, are common. Nausea and vomiting are other side effects that can affect a person's appetite and nutritional status [13].
Severe Side effects: Sometimes, Tirzepatide can cause serious side effects. These include severe stomach problems, vision changes, symptoms of a thyroid tumour, gallbladder problems, low blood sugar symptoms, and kidney problems. If you experience these symptoms, seeking medical help immediately is important [13].