Overview

Zenzedi and Dexedrine are both brand names for dextroamphetamine, which is a central nervous system stimulant that is used to treat ADHD and narcolepsy, a sleep disorder. Zenzedi comes in various forms, including tablets, oral solution (liquid), extended-release capsules, and even skin patches for adults and children over 6 years old [1]. Dexedrine, on the other hand, is available in tablets, extended-release capsules, and a liquid form [2, 3].

Dextroamphetamine works by adjusting the levels of certain natural chemicals in the brain, helping to improve focus, attention, and control over behaviour. It also helps with organising tasks and improving listening skills. For people with narcolepsy, it’s used to help stay awake during the day. However, it’s important to note that it shouldn’t be used to deal with tiredness or to stay awake if you don’t have a sleep disorder.

These medications can be habit-forming, so they should only be taken as prescribed by a healthcare provider. Misusing them can lead to serious health issues, including heart problems or even death [1].

Uses

As discussed earlier, Dextroamphetamine is a central nervous system stimulant mainly prescribed for treating two conditions: attention-deficit hyperactivity disorder (ADHD) and narcolepsy [4, 5].

Treating ADHD: When used for ADHD, dextroamphetamine helps by boosting attention and reducing hyperactivity in both children and adults who struggle with staying focused, often get easily distracted, or act impulsively. It's typically part of a comprehensive treatment plan that includes social, educational, and psychological support [4, 5].

Off-Label uses: Dextroamphetamine is sometimes used off-label by college students looking to boost memory, improve test-taking ability, or stay alert during long study sessions [6].

Treating depression and fatigue: In certain situations, it has also been prescribed for treating depression and fatigue in AIDS patients and to manage mania [7, 8]. Additionally, dextroamphetamine can be used in palliative care for cancer patients to help reduce sleepiness caused by opioid painkillers and to manage mood disorders that don't respond to other treatments [9].

Side effects

Dextroamphetamine can cause a variety of side effects.

Common side effects: Common side effects include a fast heartbeat, decreased appetite, tremors, headaches, trouble sleeping, dizziness, upset stomach, weight loss, dry mouth, and feelings of anxiety [10, 11, 4, 6].

Severe Side effects Dextroamphetamine can cause severe side effects that require immediate medical attention.

These include allergic reactions like skin rashes, itching, hives, or swelling of the face, lips, or tongue. You may also experience heart problems, such as chest pain, tightness, high blood pressure, or a fast, irregular heartbeat. Mental health issues are another concern, including confusion, hallucinations, and seizures—especially in people with a history of seizures. Other serious side effects could involve vision or circulation issues, problems with movement, slowed growth in children, or even painful and prolonged erections.

Choosing between Zenzedi and Dexedrine?

In conclusion, the choice between Zenzedi and Dexedrine should be made in consultation with a healthcare provider, considering the individual's specific medical history, current medications, and each drug's potential side effects and interactions.

Alternatives to Dextroamphetamine

Amphetamine-based medication: Amphetamine-based medications, like Adzenys, are another choice for managing ADHD. These stimulants work by improving focus and helping to rein in impulsive behaviour and hyperactivity [12].

Desoxyn: Another option is Desoxyn, which contains methamphetamine. This medication is also used to treat ADHD, helping to improve focus while reducing impulsiveness and hyperactivity [12].

Vyvanse: Vyvanse, also known as dexamfetamine, is another treatment worth considering. It’s often prescribed for ADHD and binge eating disorder. For those with ADHD, it helps sharpen focus, curb impulsive behaviours, and manage hyperactivity [12].

Methylphenidate: Methylphenidate, commonly known by its brand name Ritalin, is another option for managing ADHD and narcolepsy. For those with ADHD, it helps improve focus and reduce impulsive behaviour and hyperactivity [12].

Dexmethylphenidate: Dexmethylphenidate, sold under the brand name Focalin, is another choice for treating ADHD. It works by enhancing focus and helping to manage impulsive behavior and hyperactivity in people with the condition [12].

Atomoxetine: Atomoxetine, known by Strattera, offers another option for managing ADHD. Unlike stimulant medications, it’s a non-stimulant that can help improve focus and reduce impulsive behavior and hyperactivity in people with ADHD [12].

Bupropion: Bupropion, known as Wellbutrin, is a medication with multiple uses. It’s mainly prescribed to treat depression and seasonal affective disorder, but it’s also helpful for people trying to quit smoking [12].

Viloxazine: Viloxazine, sold under the brand name Qelbree, is another option for managing ADHD, particularly in children. It helps improve focus and control symptoms in younger patients [12].

Nortriptyline: Nortriptyline, commonly known as Pamelor, is prescribed for depression but is also used to prevent migraines and manage nerve pain [12].

Mysayis: Mydayis is a long-lasting medication that combines different types of amphetamine salts [12].

Other options: Methylphenidate patches (Daytrana) and liquid form (Quillivant) are other alternatives for treating ADHD [12].

Non-stimulant options, like clonidine and guanfacine, can also help manage ADHD symptoms [12].

It's important to remember that every medication comes with its own set of potential side effects, and it may interact with other drugs you're taking. Always check with your doctor before making any changes to your ADHD treatment plan [12].