Can you take BPC-157 with Antidepressants?

In this article, we will take a close look at BPC-157, a pentadecapeptide isolated from human gastric juice. We will explore its potential therapeutic benefits, including its role in angiogenesis and wound healing. Additionally, we will analyze its interaction with antidepressants, a crucial aspect for those considering this peptide as a supplement.
Natasha Puttick

Natasha Puttick

Graduate medical student at Barts and London.

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What is BPC-157?

BPC-157, also known as Body Protection Compound 157, is a pentadecapeptide, meaning it consists of 15 amino acids. It is a partial sequence of a body protection compound that is discovered in and isolated from human gastric juice [1, 2].

BPC-157 has been suggested to contribute to angiogenesis, the process through which new blood vessels form from pre-existing vessels [1]. It has been shown to increase vessel density both in vivo and in vitro, and accelerate the recovery of blood flow in ischemic muscle of the rat hind limb [1].

This peptide has also been found to have extensive healing effects, including the acceleration of the healing of many different wounds, such as transected rat Achilles tendon [2]. It has been demonstrated to promote the outgrowth of tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts [2].

In addition, BPC-157 has been used in clinical applications, particularly in ulcerative colitis, and has been successful in treating both external and internal fistulas [3]. It has also been shown to have a prominent effect on alcohol and NSAIDs lesions [4].

Furthermore, BPC-157 has been found to have a strong angiogenic potential, acting protectively on the endothelium, preventing and reversing thrombus formation after abdominal aorta anastomosis, and exhibiting neuroprotective properties [4].

However, most studies on BPC-157 were conducted on animals (rats), and further research is needed to understand the safety and efficacy of BPC-157. Taking BPC-157 is not recommended, and make sure to consult with a healthcare professional if you wish to take BPC-157.

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How do Antidepressants Work

Antidepressants are medications designed to alleviate symptoms of depression. They function by influencing neurotransmitters, which are chemical messengers in the brain. These drugs work by balancing certain chemicals in your brain called neurotransmitters, which help to ease your depression symptoms [5].

Influencing Neurotransmitters

One of the primary ways antidepressants work is by affecting the levels of certain neurotransmitters in the brain. For instance, Selective Serotonin Reuptake Inhibitors (SSRIs) work by preventing your blood from absorbing some of the serotonin from your brain, leaving a higher level of serotonin in the brain. Increased serotonin can help relieve depression [6].

Modulating Receptor Activity

Antidepressants also modulate the activity of certain receptors in the brain. For example, serotonin transporter antagonists enhance serotonergic neurotransmission by decreasing the functional activity of the 5-HT1A and 5-HT1B autoreceptors [7].

Inducing Neuroplasticity

Another mechanism of action of antidepressants is the induction of neuroplasticity. Chronic administration of antidepressants can lead to intracellular adaptations and increase the expression of neurotrophic factors, which play a crucial role in maintaining neural and synaptic plasticity [8].

There is little information about the interaction between BPC-157 and antidepressants. However there is some information about substances that could interact with antidepressants.

Can you take BPC-157 with Antidepressants?

Antidepressants are commonly used to treat conditions such as depression and anxiety disorders. Some examples of these medications include fluoxetine (Prozac), paroxetine (Paxil), bupropion (Wellbutrin), and duloxetine (Cymbalta) [9]. These drugs can interact with other medications, potentially leading to increased side effects or decreased effectiveness.

In the case of Lopressor, a type of beta-blocker, certain antidepressants can prevent the enzyme that breaks down Lopressor from working properly. This can cause Lopressor levels to build up in the body, increasing the risk of side effects [9].


While BPC-157 has shown potential therapeutic benefits in various conditions, its interaction with antidepressants is not well-studied. Therefore, it is crucial to consult with a healthcare provider before starting any new medication, including BPC-157, especially if you are already taking other medications such as antidepressants. They can provide personalised advice based on your health history and current medications. Check out one of our other blogs on BPC-157.

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Natasha Puttick

Natasha Puttick

Natasha is a medical student at Barts and the London school of Medicine and Dentistry, with an interest in the social determinants of health. She graduated from the University of Oxford with a BA in Human Sciences and has obtained two publications. Her most recent work investigating clinical vaccine trials has been published in BMJ Public Health.